Anti-Thyroglobulin (TG) ELISA Kit
Company : GenWay Biotech Inc
UMDC Code : 451957
Thyroglobulin (TG) is a 660 kDa, dimeric glycoprotein produced by the thyroid gland and involved in the storage and synthesis of thyroid hormones. It is the precursor of the thyroid hormones 3,3,5-triiodo-L-thyronine (T3) and L-thyroxine(T4).The enzyme thyroperoxidase (TPO) promotes iodination of tyrosine residues in thyroglobulin molecules, formingmonoiodotyrosine (MIT) and diiodotyrosine (DIT). TPO further catalyzes the intramolecular coupling of two molecules ofdiiodotyrosine to produce tetraiodothyronine (T4). TG autoantibodies are also found in some clinically euthyroid individuals, but usually at lower concentrations than inpatients with clinical disease.In addition to autoimmunity, anti-TG antibodies may develop in patients suffering from thyroid cancer. High levels of anti-TG may interfere with correct determination of serum thyroglobulin. TG is an established tumor marker for thyroid cancer,and is used post-surgically to evaluate the effectiveness of treatment and to monitor for disease recurrence.
Product URL : http://www.genwaybio.com/elisas/autoimmune-disease
Last Updated : 03/16/2013