CD175 Antibody MCA1985T
MCA1985 recognises Tn antigen on glycophorin A and glycophorin B in human erythrocytes. Tn is a cryptantigen which was recently designated CD175 at the 7th Leucocyte Typing Workshop. Tn antigen is not expressed on normal haemopoietic cells but exposure of the Tn is associated with polyagglutination.
CD209 Antibody AHP627
AHP627 recognises an epitope within the extracellular domain of human DC-SIGN. DC-SIGN was designated CD209 at the 7th leucocyte typing workshop. AHP627 detects a band of approximately 44 kD by western blot.
CD239 Antibody MCA1982T
MCA1982 recognises a non-polymorphic determinant on both the 85 and 78kD Lutheran (Lu) glycoproteins. BRIC 221 specifically recognises an epitope in the fourth extracellular domain of Lu glycoprotein. Lutheran glycoprotein is a member of the immunoglobulin superfamily and has recently been designated CD239 (B-CAM) at the 7th leucocyte typing workshop. CD239 is expressed by erythrocytes in the peripheral blood.
CD66b Antibody MCA216F
MCA216F reacts with the CGM6 gene product of the carcinoembryonic gene family. This is a 100kD, GPI anchored molecule expressed on peripheral blood polymorphonuclear cells. The antigen is expressed strongly by mature granulocytes and meta-myelocytes, but only weakly by bone marrow myelocytes. Peripheral blood monocytes and lymphocytes do not express significant amounts of the antigen.
DEHYDROEPIANDROSTERONE Antibody MCA2731
MCA2731 detects dehydroepiandrosterone (DHEA) a steroid prohormone which is the precursor of all sex steroids. DHEA is produced primarily by the adrenal glands, and together with its ester DHEA-sulphate (DHEAS), has been implicated in a wide range of physiological roles including aging, immunology, memory and obesity.
FACTOR VII Antibody MCA4680
MCA4680 recognises Factor VII, a serine protease found circulating in the blood. It initiates the extrinsic pathway of blood coagulation in conjunction with tissue factor. Tissue factor is found on the outside of blood vessels. When the vessels is damaged, tissue factor is exposed to the blood and circulating Factor VII. Once bound to tissue factor, Factor VII is activated by different proteases and converts Factor IX to IXa. Factor VII deficiency is a rare hereditary haemorrhagic disease. Symptoms range from mild to severe.
FOLLISTATIN 288 Antibody MCA4736GA
MCA4736GA recognises human follistatin isoform 288 (FS288). Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin.
IL-6 Antibody MCA5927GA
Clone AV128 specifically recognises chicken Interleukin-6 (IL-6), a cytokine that can function in either a pro-inflammtory or in an anti-inflammatory capacity. Chicken Interleukin-6 is produced by a range of cell types including macrophages, endothelial cells, T-cells and fibroblasts. Interleukin-6 is a multipotential cytokine with the ability to induce proliferation and diffentiation in B-cells and T-cells and acts as an important mediator in accute phase response.
PEPTIDOGLYCAN Antibody 7263-1006
7263-1006 is specific for the 3D polymer complex structure of peptidoglycan (PG). In a competitive immunoassay format, several compounds were found to be ineffective as inhibitors; muramyldipeptide, N-acetylglucosamine, chitin and acid hydrolyzed chitin. The epitope appears to consist of discontinuous glycan and/or amino acid residues and has not been fully defined.
VON WILLEBRAND FACTOR Antibody MCA4683
MCA4683 recognises human von Willebrand factor (vWF), also known as Factor VIII related antigen, a blood glycoprotein involved in blood coagulation. It stabilises circulating Factor VIII by binding to it and protecting it from cleavage and delivers it to sites of vascular injury. vWF also promotes the adhesion of platelets to sites of vascular damage by forming a molecular bridge between collagen on exposed endothelial cells and the GPIb binding sites of platelets circulating in the blood.