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Alkaline Phosphatase (ALP). Alkaline phosphatase is widely distributed in the body and is present in high concentrations in bone, intestinal mucosa, and renal tubule cells. Less high concentrations appear in the liver, leukocytes, and placenta. Increased values for alkaline phosphatase are found in all bone disorders, liver disease, and during the third trimester of pregnancy. Decreased values are found in hypophosphatasemia, hypothyroidism, pernicious anemia, and in dwarfs.
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