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The primary function of hemoglobin is to combine with oxygen in the lungs and to release that oxygen into the tissues. Hemoglobinopathies are disorders in which production of normal adult hemoglobin is suppressed and/or replaced by production of one or more of the many variant hemoglobins. Approximately 500 variants of hemoglobin are known, with clinical manifestations ranging from lethal to nonsymptomatic. With Beckman Coulter's Diatrac™ Glycohemoglobin Hb Aic, Hb and ACID Hb Kits, abnormal hemoglobins are detected and identified - which is of vital importance to the clinical laboratory.
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Date:
March 15, 2009
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Synthesis of hemoglobin is under genetic control and the presence of abnormal hemoglobins is associated with functional, physical and morphological abnormalities of the red cells.
Hemoglobins are composed of polypeptide chains of globin and iron protoporphyrin heme groups.
Normal hemoglobins have similar structures with a molecular weight of about 67,000 daltons and consist of 2 pairs of globin chains each associated with one molecule of heme.
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Date:
March 15, 2009
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Hemoglobin (Hb) electrophoresis on MIDIGEL permits Hemoglobin anomalies can be divided into two groups :
- qualitative anomalies : hemoglobinopathy group (D, S, E abnormal hemoglobins...)
- quantitative anomalies : thalassemia group (high rate of HbF; HbA2).
Acid hemoglobin electrophoresis on MIDIGEL Hb acid complements alkaline hemoglobin electrophoresis on MIDIGEL Hb.
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Date:
March 15, 2009
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Helena’s Hemoglobin Electrophoresis Procedure, using cellulose
acetate in alkaline buffer, is intended for the qualitative and quantitative
determination of abnormal hemoglobins.
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Date:
March 15, 2009
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I.D.-Zone Hemoglobin Electrophoresis Control
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Date:
March 15, 2009
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SPIFE Acid Hemoglobin Electrophoresis
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Company:
Date:
March 15, 2009
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Hemoglobin Procedures: AFSC Hemo Control (Cat No. 5331), AA2 Hemo Control (Cat. No. 5328) Alkaline only, REP Prep (Cat No. 3100), SPIFE/REP Dispo Cup Tray (Cat. No. 1343), Gel Block Remover (Cat. No. 1115), Applicator Blade Weights (Cat. No. 3387), Disposable Sample Cups (Cat. No. 3369), SPIFE 2000/3000 Dispo Cup Tray (Cat. No. 3370).
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Company:
Date:
March 15, 2009
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SPIFE Alkaline Hemoglobin Kits
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Company:
Date:
March 15, 2009
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The normal level glycohemoglobin product is a stabilized oxy hemoglobin control with values between 6.0 and 8.0. The elevated control has a glycohemoglobin level between 11 and 15. The values are assigned by electrophoresis and affinity chromatography methods. These product perform very well in weak cation exchange HPLC. Stability is excellent—– at least 10 days after reconstitution, 21 days frozen after reconstitution and for two years as a lyophilized powder.
HC-101 6X0.5 ml normal controls
HC-101EL 6X0.5 ml elevated controls
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Company:
Date:
March 15, 2009
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