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Angiotensin II
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Company:
Date:
December 15, 2008
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ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, major commercial laboratories, military and government facilities, and major clinics.
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Company:
Date:
December 15, 2008
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Angiotensin II (Ang II) is the most potent pressure agent known to date and is the biologically active peptide of the renin-angiotensin system (RAS). The proteolytic enzyme renin, synthesized, stored and secreted primarily by the juxtaglomerular cells of the kidneys, cleaves angiotensinogen to produce the decapeptide angiotensin I (Ang I) which is physiologically inactive. Ang I is rapidly cleaved by the angiotensin converting enzyme (ACE) in plasma, vascular endothelial cells, kidney, lung and other tissues, into Ang II, the major active component of the renin-angiotensin cascade10, 11 (see
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Company:
Date:
December 15, 2008
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The renin-angiotensin system (RAS) is cri-
tical to the control of blood pressure as
well as the preservation of salt and water
balance. Angiotensin II (Ang II) is the ac-
tive vasopressor derived from activation of
this system. Ang II is an octapeptide (MW
1045) and is generated from its inactive
precursor Ang I. The majority of circu-
lating Ang II is derived from the activity
of angiotensin-converting enzyme (ACE).
Recent Investigations indicates that the
alternative pathways also could play an
important role, especially the chimase
derived production of Ang II.
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Company:
Date:
December 15, 2008
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Angiotensin II is a primary reactive vasoconstrictor, the main stimulus for aldosterone release,
and one of the causative factors of chronic hypertension. The active angiotensin II octapeptide
is released via a tightly controlled series of prohormones and proteases as diagrammed below.
Normal human plasma angiotensin II levels are from 10-30 pg/ml when measured at rest in the
supine position; they increase on standing, exercise, dehydration, or sodium depletion. The
unique, patented 'Immobilized Antigen' technology of this angiotensin II immunometric assay
allows reliable detection of 1-2 pg/m
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Company:
Date:
December 15, 2008
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Angiotensin II
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Company:
Date:
December 15, 2008
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Quantitative Monitoring of Angiotensin II
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Company:
Date:
March 03, 2009
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This kit is intended for the quantitative measurement of angiotensin II in extracted
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Company:
Date:
March 03, 2009
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