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Myositis specific antibodies are present in 25-40 of adult patients with idiopathic inflammatory myopathies and are mostly specific for cytoplasmic t-RNA synthetases12. Of the five anti-synthetase antibodies described, antihistidyl- tRNA synthetase (Jo-1) antibodies in patients with myositis are associated with clinical features like interstitial lung disease, pulmonary fibrosis, Raynaud's phenomenon, fever and non-erosive symmetric small joint arthritis12. Antibodies against extractable nuclear antigens can be detected by various methods. Due to complexities in obtaining highly purified ENA
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Date:
January 05, 2009
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ENA are soluble ribonucleoprotein (snurps) complexes. Autoantibodies directed against various ENA have proven to be of value in the diagnosis
and monitoring of various systemic connective tissue diseases. Anti-Sm antibodies are disease specific and thus are a marker for systemic lupus
erythematosus (SLE). Antibodies to Sm occur in approximately 30-40 of SLE patients. They are rare in other systemic connective tissue diseases and if present, indicate either overlap of disease or patients that have not yet fulfilled the ARA criteria for SLE1-9. Other antibodies such as those directed against S
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Date:
January 05, 2009
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Rheumatoid autoimmune diseases are often associated with the occurence of autoanti-bodies against several nuclear or cytoplasmatic antigens. In patients with Sjögren-Syndrome antibodies against SS-A and SS-B often occur in combination. The anti SS-A protein passes the placenta and may cause the development of SLE in neonates. Each class of immunoglobulins causes a specific immunofluorescent pattern.
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Date:
January 05, 2009
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Antinuclear antibodies (ANA) occur in sera of patients with various connective tissue disorders such as systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), scleroderma, polymyositis and Sjögren’s syndrome. These ANA are directed to nuclear antigens, including DNA, nucleohistone and various extractable nuclear antigens (ENA) such as RNP, Sm, SS-A (Ro), SS-B (La), Scl-70 and Jo-11-9. These antigens are macromolecular complexes of protein and RNA. ENA are soluble ribonucleoprotein (snurps) complexes. Anti-Sm antibodies are disease specific and a marker for SLE. Antibodies
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Company:
Date:
January 05, 2009
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ENA are soluble ribonucleoprotein (snurps) complexes. Autoantibodies directed against various ENA have proven to be of value in the diagnosis
and monitoring of various systemic connective tissue diseases. Anti-Sm antibodies are disease specific and thus are a marker for systemic lupus
erythematosus (SLE). Antibodies to Sm occur in approximately 30-40 of SLE patients. They are rare in other systemic connective tissue diseases and if present, indicate either overlap of disease or patients that have not yet fulfilled the ARA criteria for SLE1-9. Other antibodies such as those directed against S
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Company:
Date:
January 05, 2009
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All reagents of this test kit are strictly intended for in vitro use only. Please adhere strictly to the sequence of pipetting steps provided in this protocol. Observe the guidelines for performing quality control in medical laboratories by assaying controls and/or pooled sera. All reagents should be stored refrigerated at 2 - 8 °C in their original container.
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Company:
Date:
January 05, 2009
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ENA are soluble ribonucleoprotein (snurps) complexes. Autoantibodies directed against various ENA have proven to be of value in the diagnosis
and monitoring of various systemic connective tissue diseases. Anti-Sm antibodies are disease specific and thus are a marker for systemic lupus
erythematosus (SLE). Antibodies to Sm occur in approximately 30-40 of SLE patients. They are rare in other systemic connective tissue diseases and if present, indicate either overlap of disease or patients that have not yet fulfilled the ARA criteria for SLE1-9. Other antibodies such as those directed against S
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Company:
Date:
January 05, 2009
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All reagents of this test kit are strictly intended for in vitro use only.Please adhere strictly to the sequence of pipetting steps provided in this protocol. Observe the guidelines for performing quality control in medical laboratories by assaying controls and/or pooled sera.
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Company:
Date:
January 05, 2009
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All reagents of this test kit are strictly intended for in vitro use only. Please adhere strictly to the sequence of pipetting steps provided in this protocol. Observe the guidelines for performing quality control in medical laboratories by assaying controls and/or pooled sera. All reagents should be stored refrigerated at 2 - 8 °C in their original container.
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Company:
Date:
January 05, 2009
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ENA are soluble ribonucleoprotein (snurps) complexes. Autoantibodies directed against various ENA have proven to be of value in the diagnosis
and monitoring of various systemic connective tissue diseases. Anti-Sm antibodies are disease specific and thus are a marker for systemic lupus
erythematosus (SLE). Antibodies to Sm occur in approximately 30-40 of SLE patients. They are rare in other systemic connective tissue diseases and if present, indicate either overlap of disease or patients that have not yet fulfilled the ARA criteria for SLE1-9. Other antibodies such as those directed against S
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Company:
Date:
January 05, 2009
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